Safety

Our Commitment to Safety
Natural astaxanthin, either as a purified haematococcus pluvialis extract or in algal biomass, has been evaluated in multiple studies to determine its potential for adverse effects and genotoxicity. The study type, study design, test materials, and findings are summarized in the tables on the following pages.

AstaReal® - The Most Studied Brand of astaxanthin
The best source of natural astaxanthin is haematococcus pluvialis microalgae, which naturally produces astaxanthin as part of its life cycle. The vast majority of the studies and research demonstrating the safety and efficacy of astaxanthin in humans have been performed by using natural astaxanthin from microalgae. Natural astaxanthin from microalgae has been on the market as a nutritional supplement for more than 15 years with no reports of adverse side effects. We have long been at the forefront of research, development, and production of natural astaxanthin from haematococcus pluvialis microalgae.

AstaReal® and Clinical Safety Studies
The clinical database for AstaReal® safety studies includes nearly 50 human studies involving more than 1,400 subjects who underwent treatments lasting from 2 weeks to 6 months (as of March 2014). The doses used in these trials ranged from 2mg to 45 mg/person/day. The trials were designed to investigate the safety and tolerance of AstaReal® astaxanthin at different doses, for different treatment durations, and with different research designs and demographic variables including age, sex, and ethnicity.

All studies revealed no adverse effects based on hematological, serum chemistry,
urine analysis, self-report questionnaires, and eye intraocular pressure (review on Kajita et al., 2010).

In 2010, AstaReal® astaxanthin esters extracted from haematococcus pluvialis microalga attained Generally Recognized As Safe (GRAS) status with successful U.S. Food and Drug Administration (FDA) notification, further demonstrating its safety under the conditions of its intended use or consumption by humans.

The specifications of AstaReal® astaxanthin were recognized as the international reference standard for astaxanthin esters derived from the microalga haematococcus pluvialis in the authoritative Food Chemicals Codex (FCC) 8th Edition published by U.S. Pharmacopeial Convention (USP) in 2012.

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